Rare Medical Conditions - Human Body Theme

Andi 0:01

This doesn't sound like something Tanner couldn't have come up with him

Sups 0:05

and he said it the moment after I shared this anecdote. And at which point do you get the superpowers?

Andi 0:12

Yeah. I think other apes have them. Yeah. I would think. I this. Of course. I was gonna ask this

Tanner 0:20

and it's about one in a million

Andi 0:23

Yeah. See now this is what I'm talking about with rare. Hello and welcome to, I should have known the trivia game show that can't be trusted. Each week, one of our quiz masters will present you with four facts about a topic, but one of them is a lie and we are exploring the human body this month and this week our quizmaster is Dr. Tanner. And he's going to be presenting us with four rare diseases or conditions except that this is a find the fake episode. So one of the conditions or diseases that he presents to us is from fiction. It is not an actual condition people have. So join me, Andy, and other host soups and trying to figure out which one it is. That's right. Mm-hmm.

Tanner 1:04

So to try to give you an idea of what we're talking about here, we'll do the pub quiz question.

Sups 1:09

Okay.

Andi 1:09

Q

Tanner 1:10

P. Q Q. So really to get you in the mind of what a fake disease would be, let's talk about a fake disease.

Andi 1:17

Ooh.

Tanner 1:18

In the TV show, game of Thrones, the character's, Shireen Baron and Jora Mormont contract a highly contagious disease that somewhat resembles a mix of real life diseases. Mm-hmm. Like leprosy, ichthyosis, Stoneman syndrome. What's the fake disease called?

Sups 1:36

I forgot. I know the, the hand start.

Andi 1:38

Yeah, when the people

Sups 1:39

it. Mm-hmm.

Andi 1:39

like leprosy. What do they call that Oh man. I know This It's killing me.

Sups 1:44

Yeah. No.

Tanner 1:46

What color does their

Andi 1:47

skin. Gray skin. Gray skin. Gray scale.

Tanner 1:49

gray scale,

Sups 1:50

Gray scale.

Andi 1:50

Gray scale. Ugh.

Sups 1:51

no,

Tanner 1:52

yeah. Gray scale.

Andi 1:53

So that's an example of a fake condition. This is not affect real people. Inspired by

Sups 1:58

real. Yeah.

Tanner 1:59

exactly. So if I was to explain grayscale to you, that's what you should be listening

Sups 2:03

Okay. With

Tanner 2:04

four diseases,

Andi 2:06

So your fake is going to be like, this? Yeah.

Sups 2:08

Okay.

Andi 2:09

Okay. Maybe we can also try to guess what the fiction it

Sups 2:13

from. Oh,

Andi 2:13

is perhaps. We'll see. Okay. Okay. Alright, I'm excited. Cool.

Tanner 2:18

Condition number one a dermato. Gly

Andi 2:21

So Gly. would be like, Marks on your skin and then a would mean you don't have any, so what marks are you supposed to have that somebody might not have? That's what this is, right? Yes.

Tanner 2:35

It's congenital absence of,

Andi 2:39

fingerprints.

Sups 2:39

fingerprints.

Tanner 2:40

fingerprints. Yes. Ah, congenital absence of

Sups 2:44

Mm-hmm.

Andi 2:45

Okay. So like men in black condition, right? Is that the movie? They do that, don't they? Yeah. They burn

Tanner 2:50

their fingerprints

Andi 2:50

off. Yeah. Yeah. Or serial killer

Sups 2:52

Yeah.

Andi 2:53

My thing is, wouldn't that make you more obvious? Yeah. So Not having them would be just as like identifying as having them.

Sups 3:00

I know. I mean, I actually, I know people. In real life. They have a lot of trouble while crossing borders, especially at the immigration, because the biometric system can't read. yeah. yeah. It just flick and they get stopped at the immigration every single time. So, I dunno if this is the definition of someone who has this condition.

Tanner 3:21

sometimes it's called immigration delay disease.

Sups 3:24

Oh, wow. Okay. That's hilarious.

Tanner 3:26

Yeah. Yeah, I love So it's a very rare genetic condition where you lack the ridges on your fingers, toes, palms of your hands, and soles of your feet, so you don't have fingerprints.

Andi 3:40

Mm-hmm. Okay.

Tanner 3:41

So it's inherited. It's a mutation in a gene. And basically when you're an embryo, when you're developing this gene is turned off. So it doesn't create these ridges, then you never have them throughout life. Mm-hmm. So it's not acquired throughout life. You're born with it, there's no treatment. But if you want to manage it, you try to identify. Without fingerprints. So facial recognition can help people with this illness If you have this, you might also have other symptoms. So you can have reduced sweat glands, which are very related to these parts of your hands and feet. You can have blistering on the skin and you can have. Small white bumps on your face. So these are the associated symptoms.

Andi 4:24

Okay. Yeah. 'cause I guess I was wondering like other than identification, which is kind of a modern thing, what are fingerprints for?

Sups 4:30

Mm-hmm.

Andi 4:31

Biologically why would we even have fingerprints? Maybe it helps with gripping or something. Or it's just a weird, I think other apes have them. Yeah. I would think. I this. Of course. I was gonna ask this. what is the biological purpose of

Tanner 4:45

Right. Because we didn't evolve them to identify each other. Yeah. You

Andi 4:49

You know, it's just a byproduct of evolution that we have fingerprints and they're unique,

Tanner 4:53

Right. it increases your uh, your gripping, your grippiness. Yeah. Yeah. You're better able to grip things. Right. So very important for

Andi 5:01

If you're a monkey,

Sups 5:02

mm-hmm.

Andi 5:02

a tree. Okay. but playing the game, I'm skeptical of this because, like how much fiction is about like sanding off your fingerprints or burning your fingerprints off. Know what I'm saying? Like it sounds like this could be an easy fake

Sups 5:16

one. Yeah. But especially the fact that he said that it's also known as immigration delay disease, which is the exact case that I was talking to you about.

Andi 5:25

Yeah. But I also think he could have invented that. This doesn't sound like something Tanner couldn't have come up with him

Sups 5:31

and he said it the moment after I shared this anecdote. could you repeat the name of the condition? Mm-hmm.

Tanner 5:38

Dermato Gly.

Andi 5:40

A ogly. Yeah. See he also could have made that up too easy

Sups 5:43

This is bunch of three Greek words put together, so, yeah, sure.

Tanner 5:48

that's medicine for you.

Andi 5:49

Yeah. make it Latin shaped for some reason. And then bam, you got a medical term. Okay, cool. So, mm, dunno right out the gate, I'm a little skeptical. I wanna hear more.

Tanner 5:59

Okay. Condition number two, hyper regenerative healing factor.

Andi 6:04

Oh, come on.

Sups 6:06

is Marvel disease.

Andi 6:07

disease.

Sups 6:08

I wanna to say Marvel straight away, like, you know. Yeah.

Andi 6:11

this is Wolverine right where you heal yourself

Sups 6:13

real fast. Okay.

Tanner 6:14

Patients with this do have above normal speeds of wound healing. Mm-hmm.

Andi 6:18

Mm-hmm.

Tanner 6:19

Associated symptoms include increased natural immunity and slowed cellular aging.

Andi 6:24

I do know the opposite's. True. There are lots of conditions and diseases that cause you to heal more slowly. Diabetes is the big one.

Sups 6:31

Yeah.

Andi 6:31

So I guess it does also stand to reason that you could heal more quickly. I mean, healing is an average thing, right? Everyone heals at different rates,

Tanner 6:39

so normal wound healing, It's weeks, it's on, on the order of weeks. Okay. Like four to six, depending on the wound. Oh, On a high traffic area like feet, it's gonna take longer. Okay. But your tongue and your mouth is actually very, very fast at healing. Mm-hmm. But these people are even faster and they also have increased reproduction of their immune cells, can also be a negative. So there's no treatment for this, but patients usually have to be screened for cancer. Because some cancers are caused by cells regenerating too much, too fast. Right.

Sups 7:10

And at which point do you get the superpowers?

Andi 7:13

Yeah. Yeah.

Tanner 7:15

This is a inborn genetic

Sups 7:17

Mm-hmm.

Andi 7:17

Mm-hmm.

Sups 7:18

But maybe this is right because this is just too simple. And I think he knows that we will know that this exists in the world of superheroes. Sure.

Andi 7:26

a trick. He is like, nah, this

Sups 7:27

that's real. Mm. Okay. But this condition is a good thing,

Tanner 7:32

Yeah. Right. There doesn't really have to be a treatment 'cause it's not detrimental to health. Mm-hmm. So it's not exactly a disease.

Sups 7:38

Okay. Yeah.

Tanner 7:39

it turns into cancer down the

Andi 7:40

road. But I guess like part of the problem there, you could have issues where like it sounds like your whole immune system is stronger and so then you would be at risk for autoimmune diseases. But then if these people aren't going in for anything, because. Why would you go in and be like, I heal too fast, doc. Yeah. Help me. Then like, how would they even know to look for this? It's very weird and then why wouldn't they be flagging these people for an autoimmune disease, Mm-hmm. So, I don't know. I think it's Wolverine but I also think, I Don't think he'd pick things so obvious. So then that's why I'm thinking maybe actually that's the trick, like is the mind games

Sups 8:18

Mm-hmm. so we are halfway there with conditions. We've got two more to go. No, both sound very, very fake to me so far.

Andi 8:28

Yeah.

Sups 8:28

see.

Tanner 8:29

Okay. Condition number three. Hyperekplexia.

Andi 8:34

Hyperekplexia. Mm-hmm. What heck? Well, hyper means too much. Too

Sups 8:39

much. Yeah. So you have too much of Plex? Yes.

Tanner 8:43

Okay.

Andi 8:43

But what's Plex?

Tanner 8:45

Plexy comes from the Greek for amazement, so it's also known as the excessive startle reaction.

Sups 8:52

Mm-hmm.

Andi 8:52

Oh God,

Tanner 8:53

So if there's an unexpected noise

Andi 8:55

uhhuh or

Tanner 8:57

You react with like Intense eye blinking body spasms. You can even like freeze up And be able to move. But you're still conscious.

Sups 9:04

Oh wow.

Tanner 9:05

It's a rare genetic neurological disorder.

Andi 9:08

Okay.

Tanner 9:09

So it's about one in 40,000

Sups 9:11

Okay. in the us. Okay.

Tanner 9:13

Right. So a lot of these people have jerking in their limbs when this happens, it's hard for them to keep their balance and they can fall.

Andi 9:21

Yeah.

Tanner 9:22

So instead of just a normal reflex, like we would have, like, if you touch something hot, you jerk your hand back. This is exaggerated for them, so it's more intense

Andi 9:29

Yeah.

Sups 9:30

Oh,

Andi 9:31

Okay. Well This one sounds very real

Sups 9:33

it's possible.

Andi 9:34

Yeah. additionally, I don't know what fiction this would come from. You know, that's the other thing about it where like, it, it makes it feel more real to me because I don't know why anyone would have that in fiction. I could see like an old timey, like, you know, like this is always the thing that's bothered me in like older fiction women faint all the time, right? So I could maybe see this as like an old timey thing like that, where you're like, yes, the weak, the gentler sex,

Sups 10:01

is that, is that your,

Andi 10:02

is that No, that's like a old timey Radio.

Tanner 10:07

Step

Sups 10:08

that's perfect.

Andi 10:09

But anyway. Yeah. So maybe if it

Sups 10:11

was fake, I

Andi 10:12

think it'd be something like that. Yeah.

Sups 10:13

Yeah.

Andi 10:14

But I mean, it does sound pretty real that some people, get startled more easily than others. but yeah. Yeah. Compared to the others though, it's definitely like harder to see where the fake, it would

Sups 10:25

yeah, could be.

Andi 10:26

All right, last one.

Tanner 10:28

Condition number four, congenital insensitivity to pain.

Andi 10:33

Ugh,

Tanner 10:34

Extremely rare genetic disorder characterized by the inability to perceive physical pain, so the absence of nociception, and this can even be inflammation or heat, they can't even feel that.

Andi 10:48

Mm-hmm.

Tanner 10:48

So they're often prone to self-injury or infections or it's harder for them to normally heal because, you know, they can't protect their healing wounds,

Andi 10:59

Yeah, that sounds terrible. I really hope that's not real. Ugh.

Tanner 11:03

Caused by a genetic mutation. Mm-hmm. Again, in certain genes that are important for pain, sensing nerves, and it's about one in a million

Andi 11:12

Yeah. See now this is what I'm talking about with rare. Yeah, That's right., But like, this is one where I feel like this one's probably real. Yeah. Because. It does sound like a superhero thing. Like it'd be great. I don't feel pain. It's awesome. I, you can shoot me, I don't care. But pain is actually useful. Pain isn't an entirely bad thing. Right,

Sups 11:31

Isn't this, I mean, the fake could also be is that there's this Marvel superhero. He also had a Netflix series. Like basically he doesn't feel pain and like bullets, like what's his name? I. Cage luke Cage. Luke Cage. Luke Cage. Yes, I know stuff.

Andi 11:45

Tan.

Tanner 11:46

I can't believe that

Andi 11:48

I I never saw the show. I just knew there's a show with that name.

Sups 11:51

Luke Cage. And it's the same thing, right? He doesn't feel pain and that's the whole point that he just calls around like, People are like shooting at him and bullets are just like flying off.

Andi 12:00

Well, but that's different. Not feeling pain does sound like a superhero thing. That's great. But like, actually I think in reality it would be

Sups 12:07

Yeah.

Andi 12:08

There's a very big difference between not feeling pain and not getting injured because this is saying your hand is, getting like burned off. Your skin is boiling, but you just don't, but you don't feel it. So you don't move your hand.

Sups 12:21

Mm-hmm.

Andi 12:21

But now your hand's messed up. I see. That's not a superpower.

Tanner 12:26

That's

Andi 12:26

terrible.

Sups 12:28

Well, for one, I can say that I don't have this condition. You don't have it? No, no, no, we don't. I don't have it

Tanner 12:35

Yeah.

Andi 12:35

I have the opposite. I have hypersensitivity, so I literally feel more pain than other people.

Sups 12:41

Yeah. So, okay, this, this sounds real, like it is possible. This I mean, we've heard four conditions, but this one to me is like a proper rare condition.

Andi 12:53

I don't think Tanner made this one up. Yeah. I don't know what fiction would have this even. Mm-hmm. Because I really do think that like, it sounds cool until you think about it one step further, pain sucks, but then you're like, oh, the pain's useful.

Sups 13:06

Yeah.

Andi 13:07

I think this one probably unfortunately real. Okay. Okay. So one of those conditions that you just presented to us is from fiction is not real. Mm-hmm. Can you repeat the four of them for us before soups and I will guess which one we think it is?

Tanner 13:21

Sure. Condition number one A dermato condition. number two. Hyper regenerative healing factor condition number three, hyperekplexia and condition number four, congenital insensitivity to pain.

Andi 13:47

One of those is not real.

Sups 13:49

See number two, if I were to pick like straight, because number two is straight out of a comic book, straight out a marvel, but then that's what makes me think like, if this is so easy, then is it fake mind

Andi 14:01

games. Yeah. My problem with the number two is not just that I can name a superhero who has that, which does kind of make me a little nervous because he would know that. I would know that. Yeah. like, I know very few superheroes, but I know that one. Right. Yeah. Yeah. okay, so like, that's my, that's one problem is that some psychological, those are some mind games you're playing by doing that. But there were other things about that one that was sketchy where it's called a factor. So I would think there'd be something in your blood that you would find, but then he didn't mention that. He only described know, having higher white blood cells or immune cells and then like the whole idea of like finding people who have this, like, it's just weird. It like too much about that one. It doesn't make sense. So it seems faked.

Sups 14:47

Okay.

Andi 14:48

Then that's the game of being like, it's too obvious. It's too obvious. So

Sups 14:51

I think it's the first one,

Andi 14:52

maybe the first one. I do think that it could be that one. Yeah. That is also from science fiction and,

Sups 14:58

the name sounds like a made up

Andi 14:59

name. The gly. Yeah. Mm-hmm. It does sound pretty fake. Yeah.

Sups 15:02

Even though we've established that I know someone who actually has this or faces this problem, but I still feel it doesn't fall under like this rare condition, or that like the whole concept is actually made out of fiction

Andi 15:15

Yeah. it does sound sketchy. I think I'm gonna still pick number two just

Sups 15:18

Okay. because I

Andi 15:19

will like kick myself if I'm like, Come on, Andy. You know, like zero superheroes, but you knew that one and you didn't pick it. Mm-hmm.

Sups 15:25

I think I'm with you on number two. I think that has the best chances of being fake, but also something about number one sounds very, very fishy.

Andi 15:33

Yeah.

Sups 15:34

So I'm gonna pick number one.

Andi 15:35

Okay.

Tanner 15:36

All right. So the moral of the story is when you

Andi 15:40

fail medical school.

Tanner 15:41

no. You guys did a very good job of looking into these, not just going with your gut and saying, forget about the other ones, because the real ones really do affect real people. And so we should remember that and they should get some care and drugs if they need it or treatment. But in medicine, go with your gut. it was Wolverine

Andi 15:58

number Yeah. Yeah. See, I would've been so mad if I didn't pick that one,

Tanner 16:04

about it

Sups 16:04

it because I knew it was fake. So

Tanner 16:06

Yes, exactly.

Andi 16:07

just

Sups 16:07

my name. Mm-hmm. Yeah.

Tanner 16:08

So the other ones they almost appearing in fiction. So, sometimes people in sci-fi have a dermato gly, but not like we talked about. It's not. From birth. Yeah. They do it to themselves exactly like you were saying. Same with congenital insensitivity to pain in X-Men and some comic books. They're experimented on and then they gain this and so like this is in Deadpool. Someone gets it. It

Andi 16:35

it sounds awful, but

Tanner 16:38

yeah. So this does not happen in real life. There's no hyper regenerative healing factor. It is in. Other animals, it's kind of similar. So some lizards

Andi 16:46

Liz can regenerate. That's true. That's true. can cut your tail off and still be good.

Tanner 16:51

Yeah. All, animals can regenerate to some degree. Like we can do this with our livers. Yeah. You can regenerate it from a few cells. So yeah, Wolverine has hyper regenerative healing factor. That's what it's called in the, in the comics. In your blood? Yeah.

Sups 17:07

Hmm. All right. I should have known.

Andi 17:09

Yeah, I should have known. Thanks for listening to this episode of I Should Have Known. We are on YouTube. If you're listening on there, please like, comment to subscribe. Let us know if you got Tanner's fake rare condition. And if you're listening on a traditional podcast platform, please leave us a review. And if you're on Spotify, you can also comment. Otherwise, get in touch with us on social media and we are going to be continuing. Our exploration of the human body. Next week we're gonna look at the extremes of the human body. So be on the lookout for that. And as always, thanks for listening. I don't know what I'm saying.